How to Make CBD Solubility in Water

CBD has no natural water solubility and can only be ingested via inhalation or edibles. Inhalation can be time-consuming and may not be a feasible option for people who want fast-acting results. This lack of water solubility has driven scientists to create ways to make cbd solubility in water so it can be ingested through beverages, pills, and other products.

Can you put water-soluble CBD oil under your tongue?

One way is by creating a nano-emulsion. This is a method that involves mixing oil and water using surfactants. The surfactants reduce the surface tension between the two liquids and create small droplets that can be suspended in the water. The smaller the droplets, the better the bioavailability. The CBD is then encapsulated in the emulsifier and can be absorbed into the bloodstream faster.

Another way to make cbd water soluble is by dispersing it into a lipid-based delivery system. This is a process that requires the use of a non-polar, non-ionic surfactant such as hexanedioic acid (HEXA) or butylene glycol. The fatty acids are used to dissolve the CBD and the non-polar surfactant keeps the CBD molecules in place. The resulting formulation is called a self-nanoemulsion.

This method has been shown to have superior dissolution properties to other methods such as physical dispersion, emulsion and co-dispersion with Neusilin US2 or Soluplus. Dissolution kinetics of the CBD, CBDA and CBC in HiE-Neusilin US2 or HiE-Soluplus showed high correlations for zero-order and first-order kinetics indicating diffusion-driven release. In addition, the CBC and CBDA profiles in HiE-Soluplus displayed higher permeability to intestinal cells than in the control samples.

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